6/7/2023 0 Comments United sketch fritzing for mac![]() ![]() ![]() DEC in head-fixed mice has been used to identify cerebellar regions 11, 12, 13, 14, 15, 16, 17 and circuit elements 11, 12, 13, 14, 15, 18, 19 that are required for task acquisition and extinction. DEC was the first associative learning paradigm to be adapted to this configuration 10, 11. More recently, climbing fiber-dependent associative learning paradigms have been developed for head-fixed mice. Further, Purkinje cell complex spikes, driven by their climbing fiber inputs 5, provide a necessary 6, 7 and sufficient 8, 9 signal for the acquisition of properly-timed CRs. In rabbits, cerebellum-specific lesions disrupt this form of learning 1, 2, 3, 4. The learned response is referred to as a conditioned response (CR), while the reflex response is referred to as the unconditioned response (UR). For example, in classical delay eyeblink conditioning (DEC), animals learn to make a well-timed protective blink in response to a neutral conditional stimulus (CS e.g., a flash of light or auditory tone) when it is paired repeatedly with an unconditional stimulus (US e.g., a puff of air applied to the cornea) which always elicits a reflex blink, and which comes at or near the end of the CS. ![]() Pavlovian conditioning of sub-second association between stimuli to elicit a conditioned response has long been used to probe cerebellar-dependent learning.
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